Quinn is well known for his five-years as a Saturday Night Live cast member, playing hysterical characters "Lenny the Lion" and "Joe Blow". On Saturday Night Live his popular catchphrase, "That's my story and I'm sticking to it" at the end of each Weekend Update is known to many fans. In addition, Quinn co-hosted MTV's popular game show Remote Control.
In addition to his impressive television credits, Quinn has appeared in several movies, including Who's the Man?, Married to the Mob, A Night at the Roxbury and most recently, Comedian. He wrote the screenplay for Celtic Pride, and also wrote and starred in the critically acclaimed Broadway one-man show, Colin Quinn: An Irish Wake. In 2004 he was honored in Comedy Central's list of the "100 Greatest Stand-Up Comics of All Time".